1. What mechanisms prevent the entire blood supply from clotting after a minor i

Question

1. What mechanisms prevent the entire blood supply from clotting after a minor injury?

2. Many viruses alter regulation of the infected host cell. For example, several viruses induce the degradation of antiviral factors. Propose strategies that could be used by the virus to accomplish this. In addition, many viruses have evolved mechanisms to inhibit cellular apoptotic pathways. Why might this be the case?

3. Proteasome inhibitors are increasingly used for cancer therapy. Why might such compounds be effective in preferentially targeting tumor cells?

Explanation / Answer

1) (a) Endothelial cells release NO, ADP dephosphatse and PGI2 . NO and PGI2 are vasodialators prevent the receptors on the platelets. ADP dephosphatse prevent the adhesion of platelet, platelet require ADP to bind to the endthelial cells.

(b)Heparin sulphate are released from endothelial cells, antithrombin 3 prevent the passage of thrombin to the healthy parts from teh injured by cleaving thrombin.

(c)tissue palsminoge activator converts plssminogen to plasmin which is a fibrin cutter.

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