1321 bp 5. Does this protein require a cofactor? If so, which one? 6. AAX09026 s

Question

1321 bp 5. Does this protein require a cofactor? If so, which one? 6. AAX09026 shows the greatest sequence identity with LDH from what other organism? humans 7. What is the PDB accession code for the L-lactate dehydrogenase most similar to AAX09026 for which a structure has been obtained? In what organisms is this? 8. What (%) is the sequence identity (and over how many amino acids) between AA09026 and the protein identified in question six? 9. How identical are AAX09026 and NP 001106720? For the non-identical amino acids in the alignment, how many of the substitutions are conservative, and how many are non-conservative? 10. Provide a biochemical/physiological explanation for why two lactate dehydrogenases from the same species (question 9) are less similar than lactate dehydrogenases from two different species (eg., in question 8).

Explanation / Answer

5. Lactate dehydrogenase is an enzyme involved in the production of energy in cells. Yes, this enzyme required a co-factor and for lactate dehydrogenase it is NAD.

6. With Bos mutus grunniens it show maximum similarity

7. 5LDH is the PDB id and is belong to pig

8. It is showing 100% sequence similarity.

9. It is showing 99% sequence similarity.

10.This is because all the organisms are thought to be involved from same ancestor. Again gene duplication followed by changes in duplicated genes, lead to the modification in the sequence of that gene.

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