e. Mutations in non-affected, wild e. All of the above tHooon excision trom the
ID: 206191 • Letter: E
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e. Mutations in non-affected, wild e. All of the above tHooon excision trom the genome, the virus"picks uo a nop type al the host b. A naturally c. A virus e occurring oncogene within a virus becomes mutae s is exposed to carcinogens, shich mutates DNA Because viruses d. mutated oncogene, and thus become e. none of the above How might oncogenes be detected? are haploid, they do not have a backup copy of the oncogenic 1 nsduction of suspect DNA into animal ransformation of suspect D rowth (i.e., lack of contact inhibition) using phage-display technology cells using a virus NA into animal cells and observation of cel C. cloning the suspect gene onto an expression vector and assaying for the presence of the defunct protein in bacterial cells d. e. none of the above h of the following does not cause a proto-oncogene to become an oncogene? a. a mutation in the co make the protein hyperactive ding region that changes the amino acid sequence to b. a mutation within the regulatory regi on of the proto-oncogene that increases expression of that gene . a duplication in the proto-oncogene d. a genetic rearrangement of the proto-oncogene that places the gene behind a strong promoter, thus increasing expression e. all of the above 9. How does Ras become an oncogene? by a mutation in the coding region of the gene that creates a loss of an important function in cell division dues involved in the binding and splitting of GTP expressed of a strong promoter a. b. by a mutation in the genetic code that alters one of three amino acid resi- c. by a duplication of the Ras proto-oncogene that results in more protein d. by a genetic rearrangement that places Ras proto-oncogene downstream e. none of the above breast, and ovarian cancers? a. Ras b. cyclin-dependent kinase c. Rb d. Myc e. none of the above 10. A mutation in which oncogene tends to occur in the later progression of lung Continued)Explanation / Answer
There are specific genes that in a mutated form or being interrupted in their expression, may produce an uncontrolled proliferation of cells. These are denominated Oncogenes and some of them can be activated by viruses called oncogenic viruses.
Viruses can’t manage their own molecular activity, that’s why they are dependent on a cell to do their molecular job. In this process, viruses can kidnap some genes from the host cells. Retroviruses are those that lack DNA molecules and carries only RNA. While infecting a cell, virus’s RNA is retrotranscripted into DNA and integrated to the host cell’s genome.
The discovery of oncogenes in retrovirus led to conclude that oncoviruses are not originally codified within the virus. Thus, oncogenic virus “picks up” an oncogene from the host. Option A is correct.
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