QUESTION 6 (a) The pedigree below is from a family in which some members have a

Question

QUESTION 6 (a) The pedigree below is from a family in which some members have a completely penetrant disease caused by a dominant mutation. This mutation is linked at a distance of 10 map units from a SNP marker with three different alleles (1, 2 and 3). The SNP alleles found in each family member are indicated below each pedigree symbol. It is not yet evident whether the very young individuals labeled A and B will develop the disease. (i) What is the probability that A will develop the disease? 13 22 12 32 (ii) What is the probability that B will develop the disease? 12 32 A B

Explanation / Answer

Probability= no of favourable outcomes / total no of outcomes

1. Total no of outcomes- 44
No of favorable outcomes- 12
Probability- 12/44
=0.27

2. Total no of outcomes- 44
No of favorable outcomes- 32
Probability- 32/44
=0.72

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