True or False: Native, fully folded proteins that are synthesized in the cytosol

Question

True or False: Native, fully folded proteins that are synthesized in the cytosol are imported into peroxisomes without unfolding.

Fill in the blank

According to Molecular Biology of the Cell, the ["retrieval", "endocytic", "secretory"] pathway leads outward from the ER toward the Golgi apparatus and cell surface, with a side route leading to lysosomes, while the ["retrieval", "endocytic", "secretory"] pathway leads inward from the plasma membrane. In each case, ["endocytic", "retrieval", "secretory" ] pathways balance the flow of membrane between compartments in the opposite direction, bringing membrane and selected proteins back to the compartment of origin.

Explanation / Answer

1. The statement is TRUE.

The Native, fully folded proteins are synthesized in the cytosol are imported into peroxisomes without unfolding.

2. According to Molecular Biology of the Cell, the secretory pathway leads outward from the ER toward the Golgi apparatus and cell surface, with a side route leading to lysosomes, while the endocytic pathway leads inward from the plasma membrane. In each case, retrieval pathways balance the flow of membrane between compartments in the opposite direction, bringing membrane and selected proteins back to the compartment of origin.

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