6. Regarding epitopes for BCRs and/or for TCRs, indicate whether each statement

Question

6. Regarding epitopes for BCRs and/or for TCRs, indicate whether each statement below (a-h) is true. (5 pts) If statement is only true for epitopes for BCRS-circle (B) If statement is only true for epitopes for TCRs-circle (T) If statement is true for epitopes for both BCRs and TCR-circle (BT) If statement is NOT true for either epitopes for BCRs or TCR-circle (N) a. epitopes may consist of non-sequential amino acids b. epitopes are often from the interior of antigen c. epitopes can be present in immunogens d. epitopes can be in foreign or self-molecules e. multiple epitopes may be present in a single antigen BIT/BT/N BIT/BT/N BIT/BT/N B IT/BT/N B IT/ BT/N 7. In a recent paternity case, authorities examined the HLA alleles of the offspring, biological mother and 3 potential fathers. The HLA alleles identified in each individual are shown in the table below. Which of the potential fathers is the most likely biological father? Explain your reasoning. (5 pts) HLA-A A3, 43 A3, 33 HLA locus HLA-B HLA-C Offspring Biological Mothe A3, 11 Potential Father 1 Potential Father 2 A Potential Father 3 A11, 43 B54, 59 B59, 78 B54, 27 B54, 27 B59, 26 C5, 8 C8, 8 C5, 5 C5, 6 C6, 8 A11, 43

Explanation / Answer

a. The epitopes of both BCR and TCR can be made of both sequential or non-sequential amino acid sequences. So, the given statement will be marked as (BT).

b. TCR can only bind to the inner aspect of the antigen with the help of antigen presenting cell. So, the given statement will be marked as (T).

c. Immunogens carry epitopes and carrier determinants that play a role in the immune response. Epitopes do not act as templates for the formation of antibodies instead, antibodies are synthesized against all antigenic conformations the immune system could possibly encounter before the actual contact with the immunogen. So, the given statement will be marked as (T).

d. This is true that epitopes can be present in both foreign and self-molecules. So, the given statement will be marked as (BT).

e. This is true for both that multiple epitopes can be present in a single antigen. So, the given statement will be marked as (BT).

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