Use the information below to answer questions 9-13 A protein on the cell membran

Question

Use the information below to answer questions 9-13 A protein on the cell membrane is composed of 250 amino acids. The membrane-spanning protein consists of 6 alpha helices. The helices are embedded in the membrane with the reverse turnip domain on the connecting the helixes extending into the cytoplasm and extracellular space. 9. poims) What is the approximate weight of the protein in kD? 10. (3 poins) If each alpha helix has 7 turns, how many amino acids are in a single alpha helix? (6 poins) Sketch the membrane-spanning domain of the protein as descobsd aboxe Deseribe the characteristics of the amino acids you would expect to find in the alpha helices and reverse turns and loops (6 poins) Propose a specific amino acid mutation that may affecet the membrane spanning domain. Sketch and explain how this mutation would affect the structure of the protein. 12.

Explanation / Answer

9. Weight of protein = no. of amino acids × 0.11 kDa

= 252 × 0.11

= 27.5 kDa

10. In 1 turn 3.6 amino acids are present.

11.

11.

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