With respect to the wild-type sequence below, identify the mutation in each alte
ID: 210747 • Letter: W
Question
With respect to the wild-type sequence below, identify the mutation in each altered sequence as one of the following types: missense mutation, nonsense mutation, frameshift mutation, reverse mutation, intragenic suppressor mutation, or intergenic suppressor mutation. For each altered sequence, more than one answer is possible. This DNA sequence encodes the last amino acids of a protein that is 270 amino acids long. The first three bolded base pairs indicate the frame and include the coding region. Inserted nucleotides are italicized. Wild type: 5...GCTAAGTATTGCTCAAGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGTTCTAATCCTACTATTTATTGACC5
Altered sequence 1:
5...GCTAAGTATTGCTCAACCGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGTTGGCTAATCCTACTATTTATTGACC5
Check all that apply.
intragenic suppressor mutation
missense mutation
intergenic suppressor mutation
frameshift mutation
reverse mutation
nonsense mutation
Altered sequence 2--changing altered sequence 1:
5...GCTAAGTATTGCTCACCGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGTGGCTAATCCTACTATTTATTGACC5
Check all that apply.
intragenic suppressor mutation
missense mutation
intergenic suppressor mutation
frameshift mutation
reverse mutation nonsense mutation
Altered sequence 3--changing altered sequence 1:
5...GCTAAGTATTGCTCCCGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGGGCTAATCCTACTATTTATTGACC5
Check all that apply
intragenic suppressor mutation
missense mutation
intergenic suppressor mutation
frameshift mutation
reverse mutation
nonsense mutation
Explanation / Answer
1. Frameshift mutation,
2. Point mutation leading to frame shift mutation
3. Silent mutation as even though two nucleotides were replaced but there was no change in the amino acid they code i.e. these was no final change in polypeptide chain.
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