With respect to the wild-type sequence below, identify the mutation in each alte

Question

With respect to the wild-type sequence below, identify the mutation in each altered sequence as one of the following types: missense mutation, nonsense mutation, frameshift mutation, reverse mutation, intragenic suppressor mutation, or intergenic suppressor mutation. For each altered sequence, more than one answer is possible. This DNA sequence encodes the last amino acids of a protein that is 270 amino acids long. The first three bolded base pairs indicate the frame and include the coding region. Inserted nucleotides are italicized. Wild type:
5...GCTAAGTATTGCTCAAGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGTTCTAATCCTACTATTTATTGACC5

Altered sequence 3--changing altered sequence 1:
5...GCTAAGTATTGCTCCCGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGGGCTAATCCTACTATTTATTGACC5

Check all that apply.

reverse mutation frameshift mutation missense mutation intragenic suppressor mutation nonsense mutation intergenic suppressor mutation

Explanation / Answer

Missense mutation is the correct answer.

This type of mutation is the change in DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene. In the sequence given above, following are the mutations, the substituted are in bold with italics :

Wild type-

5...GCTAAGTATTGCTCAAGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGTTCTAATCCTACTATTTATTGACC5

Mutated Gene-

5...GCTAAGTATTGCTCCCGATTAGGATGATAAATAACTGG3
3...CGATTCATAACGAGGGCTAATCCTACTATTTATTGACC5

The reading frame is not altered in the above mutation as there is no insertion or deletion. It is a mis-sense mutation since CAA codes for Glutamine and CCC codes for Proline and GTT codes for Valine while GGG codes for Glycine.

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