An 18-year-old male college student was brought to the emergency department of a
ID: 210942 • Letter: A
Question
An 18-year-old male college student was brought to the emergency department of a hospital with the complaints of fever, chills, and pain while walking. The patient had experienced progressively spreading boils on his left leg for the past week. The boils were painful and tender and he had fever. He had not sought medical attention earlier, hoping the infection would resolve spontaneously. His vital signs reported a temperature of 39.4 °C, pulse 112/min, resting 18/min and blood pressure 124/70 mmHg. On exam, his lower left leg was swollen and tender. The overlying skin was warm and red with multiple necrotic-appearing lesions (Figure 1). The knee joint was normal with full range of motion. Laboratory studies showed a differential of 68% PMNs and 10% bands, 16% lymphs, with a white blood cell count of 16,4004. His hematocrit was 42%, his ESR was 98 mm/hr and his C-reactive protein was 18 mg/L unit. His serum chemistries were normal. Fiaure 1 x-rays of the left femur showed soft-tissue edema without any abnormalities of the bone. Bone scans of the same area showed intense uptake in the proximal femur. Blood and wound aspirate were obtained and sent for gram stain and culture (Figure 2A & B) 1. Describe what you observed in Figure 2A &B.; The organism is catalase and coagulase positive. What organism was causing his infection? 2. Susceptibility results for this organism are seen in Figure 3. How do you interpret these susceptibility results? Explain the likely reasons for the results seen with drugs 2 and 4 3. What test is being used to test vancomycin (drug 5)? Why is this test being used and what does it show? 4. What virulence factor is particularly associated with skin and soft tissue infections (SSTis)? Explain its mechanism of action. This virulence factor and this type of antibiogram are associated with a particular strain of this organism Briefly discuss the evolving epidemiology of this strainExplanation / Answer
Vancomycin is an antibiotic drug against bacterial infections.it is particularly effective in a classs of bacteria called gram positive bacteria.it becomes purple when treated with a gram stain.
Vancomycin works by interfering the bacterium's ability to build its cell wall.thus the bacterium bursts or ruptures,as the influx of fluid is too much for it to manage.
Vancomycin blood test has other names like:
Lyphocin blood test
Vancocin blood test
Vancoled blood test
Vancomycin blood test is used to measure the amount of vancomycin in the blood.it is used to ensure that the vancomycin level is in acceptable range in the blood.
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