Amyloid fibers are associated with many fatal degenerative diseases of humans an

Question

Amyloid fibers are associated with many fatal degenerative diseases of humans and livestock. Livestock diseases such as scrapie in sheep and bovine spongiform encephalitis (BSE, or mad cow disease) have impacts on agriculture. Human diseases characterized by amyloid fibers have major emotional and economic impacts, and include Alzheimer's disease and Creutzfeldt-Jakob disease. The diagram shows two views of proteins associating to form an amyloid fiber. The image on the left shows the atoms overlying a simpler diagram. The image on the right has the atoms removed. Choose the true statements about amyloid fibrils. Select all that apply. Proteins that take on amyloid fibril structure are normally soluble. The core region of an amyloid fibril is stabilized by small hydrophilic residues. Amyloid fibrils form extracellularly in the affected tissue(s). Usually, most protein molecules fold normally, resulting in the slow onset of the amyloidoses. An amyloid fibril is made up of aggregations of different misfolded protein types. Amyloid fibrils have a great amount of Beta sheet structure. Proteins that take on an amyloid structure become soluble fibrils.

Explanation / Answer

THE CORE REGION OF AN AMYLOID FIBRIL IS STABLIZED BY AROMATIC RESIDUES.

PROTIENS THAT TAKE ON AN AMYLOID STRUCTURE BECOME INSOLUBLE

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