Problem 2 - (8 pts) A protein called titin is found in our muscles. Titin has bo

Question

Problem 2 - (8 pts) A protein called titin is found in our muscles. Titin has both strength and elasticity. The figure below shows the x-ray structure of the binding domain between two titin proteins (A and B) Z2 Z1 Z2 Z1 1) What secondary structure dominates this binding domain? (short answer, 2 pts) 2) If this protein complex was pulled as indicated by the two arrows, what would happen at the molecular level? (4 pts) 3) As compared to a single alpha-helix with a similar end-to-end length when folded which protein would have greater extension length (= unravel length) when pulled? (2 pt)

Explanation / Answer

1) In this structure, alpha helix and beta chains both are present equally. The beta chains provide elasticity due to their ability of contract while the alpha helix help the beta sheets to keep contracted.

2) If we pull the protein as shown in the figure, first all free alpha helix outside and amid domains, get straighten. After applying more force, the outside domain’s beta sheets Z2A and Z2B get start to stretch and linear. Now applying extra force, other domains also stretched fully and then we would get the linear structure of the protein.

3) Both proteins have equal flexibility. However, if we apply stretch to one alpha helix then its associated protein will have greater extension length because under the applied condition, the applying protein will be in more pressure.

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