Just looking for a good explanation for the answer given below! Thanks. 12) A pr
ID: 212014 • Letter: J
Question
Just looking for a good explanation for the answer given below! Thanks.
12) A protein sequence contains one ASP residue. You want to create a new protein sequence, with this ASP being replaced with a TYR. To do this, you first generate the cDNA corresponding to the original protein (with your own choice for the codons you use), then mutate this cDNA to get the sequence corresponding to the new protein. What is the minimum number of mutations needed? A) 1 B) 2 C) 3 D) 0 E) None of the above ASP can be represented with the codon GAU; mutating G with U, you get the codon UAU which codes for TYRExplanation / Answer
Missense mutation occurs converting (GAU) which codes for aspargine to (UAU) which codes for tyrosine. Missense mutation codes for wrong amino acid. Here Glycine is mutated to uracil(G------->U) so minimum number of mutations needed is (1) . so correct answer will be option (A).
ex- AGC CTA ------------------------> AGC TTA (DNA)
UCG GAU ------------------------> UCG UAU (mRNA)
Ser--Asp Ser--Tyr (protein)
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