uestion 1 (1 point) Most cells in your body must obtain the cholesterol they nee

Question

uestion 1 (1 point) Most cells in your body must obtain the cholesterol they need by uptake of LDL particles at the plasma membrane. The following events occur in the process of cholesterol uptake. Order these events, numbering the first step "1", and so on The endosome containing LDL particles fuses with a lysosome. LDL binds to a cargo receptor on the surface of the plasma membrane Free cholesterol is available for use by the cell. The LDL particle is released from the cargo receptor into the lumen of the endosome The clathrin coat disassembles from the surface of the endocytic y esicle. Empty LDL receptors are sorted and sent back to the plasma membrane in a transport vesicle. The endocytic vesicle fuses with an endosome.

Explanation / Answer

Step-1 LDL bind to a cargo receptor on the surface of plasma membrane.

Step-2 The LDL particle is released from cargo receptor into lumen of endosome.

Step-3 The endocytic vesicles fuse with endosome.

Step-4 The endosome containg LDL particles fuse with lysosome.

Step-5 The clathrin coat dissemble from the surfaceof endocytic vesicle.

Step-6 Empty LDL receptor or sorted and sent back to plasma membrane in transport vesicles.

Step-7 free chloestrol is available by the cell.

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