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Due Today at 11 PM MDT For newly synthesized DNA, scanning and methylation takes

ID: 212090 • Letter: D

Question

Due Today at 11 PM MDT For newly synthesized DNA, scanning and methylation takes two to four seconds to occur. Before the methyl group is added, DNA repair enzymes can still tell the template strand (grey strand) from the newly synthesized strand (red strand) based on which strand is methylated. In the following DNA sequence, there is a base-pair mismatch. If you were a bacterial repair enzyme, you would still be able to identify the parent strand based on methylation. You would remove the nudeotide of base It with a nucleotide of base Template strand Base-pair mismatch A G TTG TCA 3" New strand O Type here to search DELL FS F6 F7 F8 D F10o 3E 4 5 owE R 71 82 93 8

Explanation / Answer

You would remove the nucleotide of base G and replace it with nucleotide of base T.

The parental strand is methylated at A nucleotide from 3' to 5' direction, hence the newly synthesized strand can be detected by repair mechanism and relaces G with T at mismatch region.

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