6) Vesicle fusion is mediated by the formation of protein complexes between and

Question

6) Vesicle fusion is mediated by the formation of protein complexes between and 6) SSAY. Write your answer on a separate sheet of paper. 1) How does the lysosome maintain its particular pH and why is that pH important? What would happen if the lysosome burst and why? 8) What types of endosomes are commonly found in eukaryotic cells? Describe the main function of each. 9) Targeting of molecules, including proteins, within a cell is very specific. We have explored several different targeting events and mechanisms. In general, how do cells make sure proteins reach the correct destination? Describe one specific example of targeting.

Explanation / Answer

Ans 6) Ca2+ bound protein and cell membrane. The vesicle must wait for certain signal before binding to the cell membrane. There are certain proteins which form the vesicles by removing water. The Ca2+ is a signal which binds to protein and fuses with the target membrane.

Ans 7) Lysosomes are organelles which help in the degradation of different biological molecules with help of enzymes present in them. The pH needs to be maintained so that the intracellular material can be easily degraded. It has an acidic interior pH of around 5 and is the standard one for digestive enzymes. In order to function properly it requires an acidic environment. The low pH can be maintained by pumping in H+ ions from the cytosol into the lysosome. There are many proteins also which helps in maintaining the pH.

If the lysosomes burst open in the cells, the cells get damaged as it releases the digestive enzymes. The enzymes that are released digest the own cell material and leads to death of the cell. Hence, it is also known as suicide bags of cells.

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