#7?? Q6 AVP is released in response to o Suckling distensiorn o myometrial contr
ID: 215072 • Letter: #
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#7??
Q6 AVP is released in response to o Suckling distensiorn o myometrial contraction Q7:Oxytocin and AVP can target smooth muscle cells and cause contraction through G-protein coupled receptor aq G-protein coupled receptor as o G-protein coupled receptor ai Q8:AVP regulates blood pressure via regulation of o smooth muscle cell cell relaxation o smooth muscle cell contraction Q9:AVP regulates osmolarity via o reabsorbtion of water across at the DCT o by stimulating water loss Q10:AVP binds to a GPCR at the basolateral surface of principal distal cells o activation of calcium flux o closing of aquaporin-2 channels o movement of water channels from the basal to apical o insertion of aquaporin-2 channels at the apical surface Q11:The two major physiological roles of oxytocin are to o stimulate milk productionExplanation / Answer
7) Option 1 : G-protein coupled receptor q is the correct answer.
The oxytocin receptor belongs to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily. Apart from oxytocin, other molecules such as arginine vasopressin (AVP) and oxytocin agonists or antagonists are able, because of their similar structure, to bind to the receptor. Binding of OT to the cell surface transmembrane OTR activates the receptor which subsequently activates various intracellular signal pathways, this triggering the numerous effects of the hormone, including contraction. OTR is coupled to the Gq/11 a-class guanosine triphosphate (GTP) binding proteins. The Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) pathway is the major pathway mediating the signal of OTR after binding of OT to its receptor. Binding of OT activates, through Gq/11, PLC, which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to InsP3 and diacylglycerol (DAG).
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