In 1994, telomerase activity was discovered in human cancer cell lines. Although
ID: 215375 • Letter: I
Question
In 1994, telomerase activity was discovered in human cancer cell lines. Although telomerase activity is rarely present in human somatic tissue, this discovery indicated that humans do contain the genes for telomerase proteins and telomerase RNA. Since inappropriate activation of telomerase may contribute to cancer, why do you think the genes coding for this enzyme have been maintained in the human genome throughout evolution
Shortening of telomeres may cause chromosomal aberrations.
Shortening of telomeres may cause spontaneous apoptosis.
Shortening of telomeres may cause problems in chromosome segregation.
Shortening of telomeres may cause eroding of genetic information.
Shortening of telomeres may cause chromosomal aberrations.
b.Shortening of telomeres may cause spontaneous apoptosis.
c.Shortening of telomeres may cause problems in chromosome segregation.
d.Shortening of telomeres may cause eroding of genetic information.
Explanation / Answer
Answer (a) shorteing of telomeres may cause chromosome abberations.
Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. Thus their shortening leads to chromosome abberations.
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