2. Under physiological conditions, the Nat-K* pump transports sodium and potassi

Question

2. Under physiological conditions, the Nat-K* pump transports sodium and potassium across the membrane through the hydrolysis of ATP. This occurs in a sequence of steps A. (5pts) Beginning with the START step, put the other steps a-e (currently listed in random order) of the Na*-K* pump's mechanism in order to complete a full cycle of transport. START The protein is phosphorylated open to the extracellular side, and contains 2 K* ions. a. ATP hydrolysis, protein phosphorylation, and ADP release open the protein to the extracellular side. b. The protein binds ATP which opens the protein to the cytoplasmic side. c. The protein closes & dephosphorylates. d. 3 Na+ exit into the extracellular space, and 2 K+ enter into the protein. e. 2 K+ exit into the cytoplasm, 3 Na enter into the protein, and the protein closes. Order of steps: START- B. (3pts) Describe a condition in which the cycle would proceed in the reverse order.

Explanation / Answer

2. a.

Start- c- e- b- a-d

b. Cardiac glycoside (cardiotonic steroids- ouabain) could lead to negative Na+/K+ ATPase regulation.

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