Explain the differences in the types of glycosylation that occur in the rough ER

Question

Explain the differences in the types of glycosylation that occur in the rough ER and Golgi, discussing how the oligosaccharides differ in terms of their attachment to glycoproteins, as well as in terms of diversity.

Discuss whether it is possible for a glycoprotein to exit the rough ER containing oligosaccharide chains attached to serine or threonine residues? Explain your answer

Describe an important function of the N-linked oligosaccharide added to glycoproteins in the rough ER, discussing the general mechanism involved. •

Given the location of oligosaccharides as they are synthesized in the ER and Golgi, where do you expect these to be located once an integral membrane glycoprotein is delivered at the plasma membrane.

Describe the components of microtubules.

o What is a protofilament? What is each protofilament composed of?

• Which protein family do alpha- and beta-tubulin belong to?

o Is GTP hydrolysis is required for the incorporation of dimers into a growing filament?

o How does GTP hydrolysis affect microtubule stability?

Explanation / Answer

A protofilament is a structure that is assembled by alpha beta tubulin dimers.which then associate side by side to form microtubules, thirteen protofilaments associate to form one microtubule.

Tubulin proteins belong to globular superfamily

GTP hydrolysis is not necessary for the growth of a microtubule

GTP hydrolysis would stop the addition of tubulin to the growing end.

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