In addition to the familial pedigree, please analyze the provided pedigree shown

Question

In addition to the familial pedigree, please analyze the provided pedigree shown below. Construct a paragraph explaining the possibility of each mode of inheritance. Be sure to refer to individuals within the pedigree when constructing your response (i.e. individual I-1 has the disorder, therefore... Also, please note that heterozygotes have not been partially shaded; only affected individuals are shaded below. The trait depicted below is more likely inherited in which manner: autosomal recessive, autosomal dominant, X-linked recessive, or sex-limited? Be sure to address why or why not the trait can be inherited in a given manner. This section is worth 4 points. I-1 I-2 IV-1 IV2 IV-3 13 13

Explanation / Answer

If the trait is autosomal dominant, atleast one parent should have the disease. In the above pedigree all the parents are carriers, then this is not autosomal dominant

If the trait is sex-limited, only one sex has to show the disease phenotype. In the above pedigree, both son and daughters has disease. Thus, this is not sex limited

The trait depicted is autosomal recessive

If we see at I-1 and I-2, they are unaffected but their offspring has one affected II-3. This indicates that both the parents are carriers of one affected allele on autosomes. Inorder to get the disease, both the autosomes should have affected allele. offspring II-3 has inherited one disease autosomal allele each from parents. This results in disease.

Again II-4 and II-5 are carrier parents, resulting in diseased offspring, indicating autosomal recessive allele.

Related Questions

Navigate

• Browse (All)
• Browse I
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.