While examining the biology of HPV in class, you learned that this virus must be
ID: 216252 • Letter: W
Question
While examining the biology of HPV in class, you learned that this virus must be able to push differentiated cells back into the cell cycle in order for viral replication to occur. It turns out that poxviruses, such as vaccinia virus (VACV), can productively infect a wide variety of cell types, including both undifferentiated and differentiated (i.,e., non-dividing) cells, in an equal manner. Additionally, poxviruses do not encode viral proteins that interact with Rb or p53 like HPV does. Given what you have learned about DNA viruses thus far in the course, explain the likely reason for these differences in the biology of HPV and VACV. [7 pts.] 1.Explanation / Answer
Poxviruses are a unique type of DNA viruses because they replicate only in the cytoplasm of the host cell i.e. new copies of the viral particles are formed outside of the nucleus. Therefore, they contain a large genome that encodes for various enzymes and proteins involved in viral DNA replication and gene transcription.?
HPV virus on the other hand does not contain genes that encode for enzymes and protein necessary for viral DNA replication and gene transcription, instead depend on the host machinery. Hence, replication of viral particles is seen in differentiating cells (diciding cells) as the replication machinery in these cells are active.
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