While examining the biology of HPV in class, you learned that this virus must be
ID: 216925 • Letter: W
Question
While examining the biology of HPV in class, you learned that this virus must be able to push differentiated cells back into the cell cycle in order for viral replication to occur. It turns out that poxviruses, such as vaccinia virus (VAcV), can productively infect a wide variety of cell types, including both undifferentiated and differentiated (i.,e., non-dividing) cells, in an equal manner. Additionally, poxviruses do not encode viral proteins that interact with Rb or p53 like HPV does. Given what you have learned about DNA viruses thus far in the course, explain the likely reason for these differences in the biology of HPV and VAcV. [7 pts.] 1.Explanation / Answer
HPV
In HPV the types are divided into five genera based on their differnces in their DNA sequence with individual types
VIRUS STRUCTURE
It is an non -developed icosahedral structure mostly arround 50 - 60 n.m in diametre
Genomes comprise of double stranded circles and having 8000 base pairs
PREVALENCE
HPV detection in the absent apprent disease that found in MEN 50-80% and WOMEN in 11-12%
INCIDENCE
HPV mostly cervical disease isrecorded
Other than that hish risk recorded in oral cavity arround 5%
VACV
It is an sigle stranded that is an 70bp oligo neuceotide containing of an viral DNA
Unlikely it is not an double standard which cannot counter pair with another DNA
It include IFN in a TRL,DA-1 and RNA poll indepndent
In this STING,TBK -1 and IRF-3 are depndent
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