6. Proteins listed below contain a common domain that allows them to bind to a s

Question

6. Proteins listed below contain a common domain that allows them to bind to a specific type of receptor. Using online resources, identify the common domain of these proteins an receptor they are capable of binding to. PLCy GRB2 ABL2 Adapter molecule crk proto-oncogene c-Src 7ee o,and on 8. The angiopoietins and Tie2 form an endothelial-specifie signaling system that regulates blood and lymphatie vessel development. Angl stabilizes the matured blood vasculature and limits responses to iniuries (inflammation) whereas increased levels of Ang2 promote tumor blood vessels formation, metastasis and inlammation, In this signaling system, identify core components of cellular signaling illustrated in the cartoon below using provided list 1. Antagonist: 2. Agonist: 3. Receptor (also identify a type of receptor): 4. A downstream enzyme that is activated by this signaling: 5. A downstream enzyme that is inhibited by this signaling: Ang-1 Ang-2 Tie2 Ang-2 fHl Ang-1 Censitutively Perlcyte -Considering the action mechanism between Ang1 and Ang2, design a drug that will be useful to suppress tumor blood vessels formation.

Explanation / Answer

6) PLC gamma SH2 domain attaches to specific phosphorylated tyrosine growth factor receptors, and succeeding Tyr783 phosphorylation the PLC gamma's enzymatic activity is increased, causing to phosphatidylinositol hydrolysis.

GRB2 SH2 domain attaches to a particular phosphotyrosine residue in the stimulated receptor. GRB2 consist of two SH3 domains, bind to and stimulate Sos. Hence, GRB2 role as an adapter protein for the EGF receptor.

A cytoplasmic tyrosine kinase ABL2 that is analogous to but different from ABL1. The proteins similarity involves the domains tyrosine kinase and spread amino-terminal to involve the SH2 as well as SH3 domains.

Adapter molecule crk: This gene encodes adapter protein family member which joins to different tyrosine-phosphorylated proteins. This gene product has various SH2 and SH3 domains (src-homology domains) and is participated in different signaling pathways, enlisting cytoplasmic proteins in the proximity of tyrosine kinase over SH2-phosphotyrosine interaction. The N-terminal of this protein SH2 domain role as a positive regulator of transformation while the SH3 domain C-terminal functions as a negative regulator of transformation.

Proto-oncogene tyrosine-protein kinase Src, also called as proto-oncogene c-Src, is a non-receptor tyrosine kinase protein. C-Src involves an SH2 domain, an SH3 domain, also a tyrosine kinase domain.

7)

G proteins, also called as guanine nucleotide-binding proteins (GPCR), are a protein family that inside cells behave as molecular switches, and are participated in signals transmission from different stimuli outside a cell to its interior. Their activity is controlled by factors that regulate their capacity to bind to also guanosine triphosphate (GTP)  hydrolyzes to guanosine diphosphate (GDP). They are on when bound to GTP, and they are off, when they are bound to GDP. G proteins belong to the larger enzymes groups known as GTPases.

G proteins consist of two classes. The first role as monomeric small GTPases, whereas the second behave as  G protein heterotrimeric complexes. The second class of complexes is made up different subunits that are alpha (?), beta (?) and gamma (?) subunits.

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