Academic Integrity: tutoring, explanations, and feedback — we don’t complete graded work or submit on a student’s behalf.

Prolonged use of lithium to treat bipolar disorder can cause damage to the kidne

ID: 218785 • Letter: P

Question

Prolonged use of lithium to treat bipolar disorder can cause damage to the kidneys such that epithelial cells of the collecting duct cannot insert aquaporin channels in their membranes. Which one of the following symptoms would you least expect in a person with such kidney damage? Could you explain how you got the answer?

polyuria (excessive urine production)

polydipsia (frequent drinking)

excessive thirst

high levels of vasopressin secretion

glucosuria (glucose in the urine

A.

polyuria (excessive urine production)

B.

polydipsia (frequent drinking)

C.

excessive thirst

D.

high levels of vasopressin secretion

E.

glucosuria (glucose in the urine

Explanation / Answer

E. glucosuria (glucose in the urine)
This is because 98% of the glucose reabsorption occurs in the S1 proximal tube.