Question: Cycloheximide is a protein synthesis inhibitor. What would you observe

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Question:

Cycloheximide is a protein synthesis inhibitor. What would you observe for the change in activities of PKA, GP, and PP when otherwise normal liver cells are treated simultaneously with epinephrine and cycloheximide?

A. PKA activated; GP activated; PP activate

B. PKA remains inactive; GP remains inactive; PP remains inactive

C. PKA remains inactive; GP remains inactive; PP remains active

D. PKA activated; GP activated; PP inactivated

E. PKA inactivated; GP inactivated; PP activated

What specific amino acid substitution would you make in Glycogen Phosphorylase (GP) that would exhibit the same activity that normal GP would exhibit in a liver cell treated simultaneously with epinephrine and cholera toxin?

A. A specific S on GP was changed to A

B. A specific S on GP was changed to E

C. A specific A on GP was changed to S

D. A specific E on GP was changed to S

E. A specific Y on GP was changed to E

Explanation / Answer

Cycloheximide is a protein synthesis inhibitor. What would you observe for the change in activities of PKA, GP, and PP when otherwise normal liver cells are treated simultaneously with epinephrine and cycloheximide?

D. PKA activated; GP activated; PP inactivated

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