mutant, causes 7. Presenilin 1 is one of the genes that, w familial Alzheimer di

Question

mutant, causes 7. Presenilin 1 is one of the genes that, w familial Alzheimer disease. It is also expressed i causes heart. Certain mutations cause a condition tha heart failure. In the Esposito family, alofthls to who have or had heart failure have the follow sequence for the presenilin 1 gene: GATGAT G G G. Family members with healthy hearts have the sequence G ATGGTGGCGGG. How do the enc amino acid sequences differ between the healthy and s family members for this part of the gene? xpressed in th e relativ Ives partial ATGGC

Explanation / Answer

1. Disease gene is - GAT GAT GGC GGG -

2. Healthy gene is - GAT GGT GGC GGG -

- m-RNA transcribed from diseased gene is - CUA CUA CCG CCC-

- mRNA transcribed from healthy gene is - CUA CCA CCG CCC-

- Amino acid transcribed from diseased gene - Leu-Leu-Pro-Pro

- Amino acid transcribed from Healthy gene- Leu-Pro-Pro-Pro

In the second place of the amimo acid there is change from Proline to Leucine Aminoacids.

Hopefully this helps thanks.

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