Case 1 - Muscle Physiology Prior to intubation for a surgical procedure, the ane

Question

Case 1 - Muscle Physiology Prior to intubation for a surgical procedure, the anesthesiologist administered a single dose of a neuromuscular agent, succinylcholine, to a 23-year-old female to provide muscular relaxation during surgery and to facilitate the insertion of the endotracheal tube. Following this, the inhalation of anesthetic was administered and the surgical procedure completed. What prevents acetylcholine (ACh) from accumulating at the neuromuscular junction and causing sustained contraction in a normal individual? 1. 2. How does succinylcholine work? Does the arrow poison curare work at the same location in the neuromuscular junction and in the same way? Explain. 3. Match the drug category on the left with the treatable condition on the right. A. corticosteroids B. gold compounds C. NSAIDs D. skeletal muscle relaxants muscle spasticity osteoarthritis; bursitis rheumatoid arthritis severe inflammation

Explanation / Answer

answer 1. The enzyme acetylcholniesterase prevent the acetylcholine to accumulate at the neuromuscular junction and also causes a sustained contraction in an individual.

Answer 2. ACh binds to acetylcholinesterase and hydrolysed by it into acetyl and choline. But succinylcholine resemble the structure of ACh and therefore it binds to acetylcholinesterase, which can not be hydrolyse by the it. due to which sodium channel remain close and thus muscle remain relax until the succinylcholine is not removed from body. As when ACh again bind to acetylcholinesterase ACh is broken down by enzyme and thus muscle relaxation occurs.

Answer 3 corticosteroids -- rheumatoid arthritis

Gold compound-- severe inflammation

NSAIDs-- oestoarthritis ; busritis

Skeletal muscle relaxants -- muscle spasticity

Related Questions

Navigate

• Browse (All)
• Browse C
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.