3 A) Which of the following statements regarding signal sequences is NOT true? T
ID: 219876 • Letter: 3
Question
3 A) Which of the following statements regarding signal sequences is NOT true?
The di-arginine sorting sequence can be located anywhere in the cytoplasmic domain of an ER-resident protein.
A protein with a KDEL sequence localizes to the ER via COPI retrieval.
The KDEL receptor contains a C-terminal Lys-Lys-X-X sequence.
Proteins modified with a mannose-6-phosphate localize exclusively to the lysosome.
3 B) Which of the following statements regarding clathrin-coated vesicles is FALSE?
Adapter complexes provide the specificity of vesicle cargo.
Membrane proteins containing a Tyr-X-X-? sequence are recruited into clathrin/AP3 coats.
Clathrin-coated vesicle assembly is mediated by the GTPase ARF.
Dynamin is required for pinching off clathrin-coated vesicles.
Explanation / Answer
3 A) The di-arginine sorting sequence can be located anywhere in the cytoplasmic domain of an ER-resident protein.
Reason: It should be located at specific location e.g. at N-terminus of cytoplasmic domain.
3B) Membrane proteins containing a Tyr-X-X-? sequence are recruited into clathrin/AP3 coats.
Reason: They interact with AP2 assembly particles not with AP3.
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