Intracellular hormone receptors commonly bind membrane-soluble signal molecules

Question

Intracellular hormone receptors commonly bind membrane-soluble signal molecules (steroids) that can diffuse across membranes and into a cell, and subsequently regulate transcription factor binding to promoters. Based on what you know about the logic of cell signaling pathways and responses, which of the following cell behaviors would be the best candidate for regulation via such an intracellular hormone receptor scheme? A) A white blood cell pursuing a bacterium B) Smooth muscle contraction C) Skeletal muscle contraction D) Changes in a cell's lipid metabolism profile (i.e. making more or fewer lipid synthesis enzymes) E) A 'fight-or-flight' signal, such as that mediated by adrenaline

Explanation / Answer

Answer=

Intracellular hormone receptors commonly binb membrane soluble signal molecules or steroids that can diffuse across

membrane & into cell & subsequently regulate transcription factors binding to promoters

the best candidate via this regulation scheme is

E] A Fight or flight signal such as that mediated by adrenaline

Explaination= Some extracellular signalling molecules like steroids Example is adrenaline diffuse through the plasma membrane & bind intracellular receptors present in cytoplasm or nucleus

By virtue of their hydrophobic nature ,they traverse the plasma membrane & exerts their effect within cell ,where they control the activities of specific genes

Adrenaline hormone bind to specific receptor proteins within the cell which interact with hormone response element

When adrenaline binds Beta adrenergic receptors is coupled to G proteins

which activates adenylate cyclase

Activated adenylate cyclase catalyses synthesis of cyclic AMP

There is activation of protein kinase enhance the conversion of glycogen to glucose 1 phosphate by stimulating glycogen degaradation

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