Which of the following is true of MMPs? In carcinomas, most MMPs are produced by

Question

Which of the following is true of MMPs? In carcinomas, most MMPs are produced by stromal cells rather than the tumor cells themselves. MMPs tend to degrade growth factors present in the ECM. All MMPs are membrane bound and therefore cleave substrates in the immediate vicinity of the cells that produce them. MMPs are normally expressed only during development, so MMP expression in adults is typically restricted only to tumorigenic processes. Which is true of cell motility? Lamellipodia are sheetlike structures that form at the trailing edge of motile cells. Filopodia are a subset of lamellipodia that fail to attach to the substrate and thus are swept back to the cell as membrane ruffles. Rac inactivation is required for the formation of lamellopodia. Epithelial cells can be induced to become motile by the scatter factor HGF. Which of the following is true? The number of lymph nodes containing metastatic cells is usually predictive of prognosis, at least in breast cancer. Occult metastases are typically rapidly growing. Prostate cancer metastases have the greatest likelihood of colonizing the lungs and brain. Colon cancer metastases colonizing the liver is a good example of the "seed and soil" hypothesis.

Explanation / Answer

Answer:

8) c

All MMPs are membrane bound

MMPs has three membrane proteins 1) Propeptide, 2) Catalytic domain, 3) C-terminal domain(hemopexin)

9) d

Hepatocyte growth factor (HGF) induces epithelial cell motility.activation of the epidermal growth factor receptor (EGFR) essential for cell motility.

10) a

In breast cancer, metastasis first observed in the lymph nodes

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