Experimental Trials The major purpose of a random assignment in a clinical trial

Question

Experimental Trials

The major purpose of a random assignment in a clinical trial is to: a. Help ensure that study subjects are representative of the general population b. Reduce selection bias in subject allocation to treatment c. Facilitate double blinding d. Facilitate measurement of outcome variables The purpose of a double-blind study is to: a. Avoid observer and subject bias b. Avoid observer bias and sampling variation c. Avoid subject bias and sampling variation d. Achieve comparability of treated and untreated subjects A crossover design: a. Never includes a washout period b. Is not a type of randomized clinical trial c. Uses multiple control groups d. None of the above Which of the following is a disadvantage of the crossover design? a. Since the same subject receives both treatments, there is no possibility of covariate imbalance. b. Allows change of allocation probabilities as study progresses c. Each patient is used several times, thus enhancing study statistical power d. None of the above. Concerns with eligibility criteria do NOT include: a. Cost b. Availability of the target population c. Potential compliance issues d. Whether other potential concurrent illnesses be present which would confuse evaluation of the study endpoint(s)

Explanation / Answer

1. B. Reduces selection bias in subject allocation to treatment

2.D. Achieve comparability of treated and untreated substance

3. C. Uses multiple control groups

4.C Each patient is used several times thus enhancing study statistical power

5. C. Potential compliance issue

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