Which of the following is not a GPCR? Thyroid Hormone Receptor Vasopressin V1 re

Question

Which of the following is not a GPCR? Thyroid Hormone Receptor Vasopressin V1 receptor Calcium Receptor Muscarinic receptor Angiotensin AT1 receptor Which of the following statements concerning GPCR (7TM) is true? Their activation involves phosphorylation of GDP to form GTP on the G-protein alpha subunit. Heterotrimeric G-protein binding occurs only at the C-terminal tail of the receptor. Their activation is terminated by alpha-subunit catalyzed hydrolysis of GTP to GDP. Upon hormone binding, the membrane-spanning subunits of a GPCR form an ion channel. Upon hormone binding, there is activation of an intrinsic tyrosine kinase that is associated with the N-terminus of the receptor.

Explanation / Answer

G-protein-coupled receptors (GPCRs) are the largest & diverse group of membrane proteins in eukaryotes which respond to a variety of external signals. The 7TM is receptor is used with GPCR except some receptors with seven transmembrane domains which do not signal through G proteins.

23. So, the answer for this is thyroid hormone receptor, rest all are GPCR.

24. The correct answer is that their activation is terminated by alpha subunit catalyzed hydrolysis of GTP to GDP.

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