oxygen binc ,the oxygen binding curves below for questions 3-6. The curves below

Question

oxygen binc ,the oxygen binding curves below for questions 3-6. The curves below represent ing to two types of hemoglobin-"normal" -which has a Kd of 27 torrs and a mutant form of hemoglobin called Beth Israel. The third curve shows oxygen binding to " strippe Beth Israel. 3. (2 pts) The y-asxis in Figure I represents? Clearly explain, in a few words, what this Cleary means. 4.(3pts) Clearly label the curves. HbBI for hemoglobin Beth Israel, HbA for normal hemoglobin, sHbBI for 1.00 0.90 0.80 0.70 0.60 0.50 0.40 0.30 0.20 0.10 -- stripped HbBI. 5.(2 pt) What is the Kd for HbBI? : Figure 1, Oxygen binding curves 0 10 20 30 40 50 60 70 80 90 100 110 120 for normal and Beth Israel hemoglobin, at pH 7.4. NEngl J Med (1976) 296, 125-130. po2 (torr) 6. (3pts) Estimate, using Figure 1, the percent oxygen carried by HbA from the lungs that would be delivered to tissues that have a pO2 of 20 torrs Assume that the pO2 level in the lungs is 120 torrs. Extra Credit #1 (4 pts) Compare the answer to Q11 to the percent that would be delivered by HbBI. and provide a conclusion.

Explanation / Answer

The Y-axis represents the saturation of haemoglobin with oxygen. As the oxygen is bound to haemoglobin, the saturation increases. With higher partial pressure of oxygen, there will be a higher saturation of haemoglobin with oxygen.

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