6. An intravenous dose of axzithromycin is usually prepared by injecting a measu

Question

6. An intravenous dose of axzithromycin is usually prepared by injecting a measured small amount of sterile water into a sealed vial containing a specific known amount of solid formulation containing the medication and shaking the vial until all of it is dissolved. The dosage to be administered to a patient is then removed (with a syringe) and added to a specific volume of diluent solution, which is then administered as an IV drip. A diluent solution that is commonly used is 1/2 normal saline (0.45% sodium, chloride solution). If an azíthromy in formulation contains 500 mg of azithromycin and sterile water is added to make 5 mL of the formulation, how much must be removed with the syringe to add to the diluent solution for a dosage of 80 mg Gpoints) 7. (10 points) According to the nursing notes, at least 36 minutes passed before the hospital staf realized something was wrong. Azithromycin is usually administered intravenously over a concentration range of 1.0-2.0 mg/mL over a period of one hour. Consider a hypothetical situation whereby a dose of 500 mg of azithromycin is administered at 2.0 mg/ml of azithronycin in ½ normal saline. (a) How many mg of medication would have been administered every 15 minutes? (b) Plot a graph of dose administered vs. time. (c) Using the graph only, determine how much medication would be administered in 36 minutes (d) What % of medication (relative to the total dose of 500 mg) would be administered by 36 minutes? e) How much saline solution would have been administered for a dosage of 500 mg in 36 minutes?

Explanation / Answer

The dosage is 500 mg in 5 ml. This means 1 mL contains 100 mg of the azithromycin. To make the dose of 80 mg, the total volume of solution should be 0.8 mL. So, from the total mixture 4.2 mL should be removed to add the diluent, hence the total concentration of 80 mg and total volume is 0.8 mL.

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