6. An intravenous dose of azithromycin is usually prepared by injecting a measur

Question

6. An intravenous dose of azithromycin is usually prepared by injecting a measured small amount of sterile water into a sealed vial containing a specific known amount of solid formulation containing the medication and shaking the vial until all of it is dissolved. The dosage to be administered to a patient is then removed (with a syringe) and added to a specific volume of diluent solution, which is then administered as an IV drip. A diluent solution that is commonly used is 1/2 normal saline (0.45% sodium chloride solution). If an azithromycin formulation contains 500 mg of azithromycin and sterile water is added to make 5 ml. of the formulation, how much must be removed with the syringe to add to the diluent solution for a dosage of 80 mg? Bpoints)

Explanation / Answer

Ans. Concertation of azithromycin in diluted formulation =

Mass of Azithromycin / Volume of sterile water in mL

= 500 mg / 5 mL

= 100 mg/ mL

# Required volume of above formulation =

Required mass of Azithromycin / [Azithromycin] in formulation

            = 80 mg (100 mg/ mL)

            = 0.80 mL

Therefore, required volume to be added to the diluent solution = 0.80 mL

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