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Please help fill the chart and answer question #4 Activity 1: Determine the dopa

ID: 238286 • Letter: P

Question

Please help fill the chart and answer question #4

Activity 1: Determine the dopamine levels in each dopamine tract in schizophrenia patients without treatment, schizophrenia patients with 1st generation antipsychotic treatment and 2nd generation antipsychotic treatment, compared to non-schizophrenia patients. Also, determine the dopamine tract that is involved in positive vs. negative symptoms of schizophrenia, determine the effect of 1st generation vs. 2nd generation antipsychotic treatment on positive and negative symptoms, and possible adverse effects. DA levels in schizophrenia pt without treatment; associated symptoms DA levels in schizophrenia pt with 1st DA levels in schizophrenia pt with 2nd generation antipsychotic; effect ongeneration antipsychotic; effect on associated symptoms; adverse effects associated symptoms; adverse effects Name of Dopamine Tracts

Explanation / Answer

Nigrostriatal

NAMES OF DOPAMINE TRACTS DOPAMINE LEVELS IN SCHIZOPHRENIA Pt WITHOUT TREATMENT;ASSOCIATED SYMPTOMS DOPAMINE LEVELS IN SCHIZOPHRENIA Pt WITH 1ST GENERATON OF ANTIIPSYCHOTICS;EFFECTS ON ASSOCIATED SYMPTOMS AND ADVERSE EFFECTS DOPAMINE LEVELS IN SCHIZOPHRENIA Pt WITH 2ND GENERATION OF ANTIPSYCHOTICS ;EFFECTS ON ASSOCIATED SYMPTOMS AND ADVERSE EFFECTS Mesocortical generally dopamine levels are high in schizophrenia .ths abnormal function of the dopamine is the man cause for schizophrenia . CHLORPROMAZINE: it is a phenothiazine ,D2 receptor antagonist ,the associated effect is sedation and weight gain ;side effects are drowsiness ,anxiety, breast swelling or dscharge ,changes in menstruation ,constipation,blurred vision aripiprazole : headche nause constipation Mesolimbic the associated syptoms are frontal lobe is underactive and parietal lobe is overactive . Fluphenazine:it blocks the post synaptic dopamenergic D1 andD2 receptors ,and also have alpha adrenergic and anticholinergic:side effects are nausea, lethargy, drowsiness ,loss of appetite

Nigrostriatal

when frontal lobe is underactive the associated problems are planning organization and violation all are impaired,which gives negative symptoms of schizophrenia haloperidole:it is a D2 antagonist and noted for high potency and low potential for causing orthostatis ;side effects are mild itching skin rash ,breast enlargement , interest in sex , feelng restless and anxious olanzapine:weight gain and nsulin resistance Tuberoinfundibular the associated problems with the parietal lobe are distoration of the all senses and perception ,whch gives the positive symptoms of schizophrenia   perphenazine :blocks the post synaptic dopmenergic receptors and associated effects are alpha adrenergic blocking effects :side effects are drowsiness, headache , anorexia, sleep problems and strange dreams Quetipine : constpaton and dry mouth thiothixene :its a D2 antagonist with anticholinergic and alpha blocking effects :side effects are nausea ,vomiting, menstrual changes ,dry mouth ,increased thirst. Trifluperazine:it s an piperazine penthothiazine agent whgich is an antagonist of post synaptic mesolimbic dopmenergic D2 receptor : side effects are twitching, uncontrollable movement of the eyes lps tongue ,face arms  
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