. Why would an angioplasty patient receive antibiotic therapy before and/or afte
ID: 239140 • Letter: #
Question
. Why would an angioplasty patient receive antibiotic therapy before and/or after the procedure if they were not demonstrating any signs of infection? 2. Dr. Scott's empiric therapy utilized Cefazolin and Amikacin. a. Identify the category or type of antibiotic that each drug belongs to, e.g., penicillins or tetracyclines. b. Briefly, describe the mechanism of action of each drug, i.e., how does it interact or interfere with it's target? . Why would he choose such a combination therapy? 4. What is the WBC count of an otherwise healthy individual? s. Is Lee's WBC count consistent with his other symptoms? Explain.Explanation / Answer
Answer:
After an angioplasty, antibiotics are given generally to prevent coronary artery stent infections , which have high mortality rates.
2.a)Category or type to which the drugs belong to:
b)Mechanism of action of Cefazolin:
Cefazolin inhibits cell wall biosynthesis by binding Penicillin binding proteins which stops peptidoglycan synthesis. Penicillin binding proteins are bacterial proteins that help to catalyze the last stages of peptidoglycan synthesis, which is needed to maintain the cell wall. Cefazolin inhibits cell wall biosynthesis by binding Penicillin binding proteins which stops peptidoglycan synthesis. Penicillin binding proteins are bacterial proteins that help to catalyze the last stages of peptidoglycan synthesis, which is needed to maintain the cell wall. They remove the D-alanine from the precursor of the peptidoglycan. The lack of synthesis causes the bacteria to lyse because they also continually break down their cell walls. Cefazolin is bactericidal, meaning it kills the bacteria rather than inhibiting their growth
Mechanism of action of Amikacin
Amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin.
3.Why did the doctor choose combination therapy of amikacin and Cefazolin
Synergestic(combination) activity of amikacin and Cefazolin is proved to be effective against most oxacillin resistant stains of bacteria.
The internal mechanism of the bacteria such as protein synthesis and nuclear division may not halt soon after giving cefazolin, the cell wall intergrity is only broken. The now broken cell wall allows Amikacin to enter and exhibit activity against 30S ribosomal subunit, leading to a misread genetic code and inhibited translocation of the bacteria. Thus,the two antibiotics truly work together, leading to shorter time to kill the micro organism.
4.WBC count of a normal individual
Total WBC : 4,500 - 10,000 cells per micro liter of blood.
5.Is Lee’s WBC count consistent with his other symptoms? Explain
Yes. Mr. Lees WBC count was 16,000 cells per micro liter of blood. A high white blood cell count usually indicates: An increased production of white blood cells to fight an infection.The patient exhibits other signs of infection like temperature 101.4 F, tender, warm reddened area around IV site. His blood culture grows Acenetobacter baumannii. Hence Lee’s WBC count is consistent with his other symptoms of infection and he is being treated with antibiotics.
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