½ 22. People of Asian descent get more drunk than other ethnicities: (Alue)(B) f

Question

½ 22. People of Asian descent get more drunk than other ethnicities: (Alue)(B) false Thiopental is given IV (MW 242; LogP 2.6). Which graph lines in the figure (right) most closely uod- approximates the concentration of thiopental in 23.Plasma 24.Kidney 25.Brain 1 2 4 8 12 16 20 30 Time (hours) 26.Which ONE of the following is not used for hepatic drug conjugation c. glucoronic acid d. Lactic acid a Glycineatg oFnsprstion ulfate Decanoke acid ILES cicc(ccc1C( eridol 172.27 4.30 40.54 26 375.87 natons

Explanation / Answer

22. Answer is True

Asians are great drinkers. Because the metabolizing isn’t quite done yet. The acetaldehyde that originated after the first step still isn’t the acetic acid and water it’s supposed to be. This process is caused by another enzyme called acetaldehyde dehydrogenase 2 (ALDH 2).

23. Plasma. - D, within 1-2 HR, the theopental level in plasma reaches it's peak and then declined further.

24. Kidney. - c

25. Brain. - D

26. Answer is option D Lactic acid

Phase II reactions involve conjugation with an endogenous substance (eg, glucuronic acid, sulfate, glycine); these reactions are synthetic.

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