QUESTION 4 Which of the following is not a barrier to recovery in spinal cord in
ID: 253043 • Letter: Q
Question
QUESTION 4
Which of the following is not a barrier to recovery in spinal cord injury?
CSPGs
The glial scar
Local macrophage/microglial activity at the injury site
The limited recovery potential of CNS axons
QUESTION 5
Which of the following is false about maternal immune activation?
It primarily affects circuit formation through microglial pruning
Neural network changes as a result of MIA may not cause disease, but could result in a higher risk of "second-hit" insults developing into disease
Children born following flu season have a higher risk of developing ASD and schizophrenia
Colonization of the microbiome is not related to immune activity
QUESTION 6
Which of the following is not a molecular mechanism of depression?
Reduced serotonin levels at the synapse
Mutations in SERT resulting in excess serotonin at the synapse during development
Reduced BDNF production resulting in hippocampal atrophy
The ability of cortisol to negatively regulate its own production is impaired
Explanation / Answer
Ans 4 : CSPGs
CSPGs are chondroitin sulfate proteoglycan , which gets produced denovo following a CNS injury. It plays a major contributory role in the repair proces though earlier it was considered otherwise.
Infact the inhibition of CSPG after the injury causes a major obstacle in the repair process.
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