132 Case Study Exercise 15 pi and Microbial Growth CASE STUDY QUESTIONS 1. How a

Question

132 Case Study Exercise 15 pi and Microbial Growth CASE STUDY QUESTIONS 1. How are the symptoms in this case-double vision, shortness of breath, slurred muscle weakness-consistent with botulism? speech, a diminished gag reflex, and 2. C. botulinum endospores are commonly found on garlic, onions, potatoes, and carrots. What do common that makes the presence of these spores not surprising? 3. Vibrio cholerae is the bacterium responsible for chodera, a disease of the cells must be ingested to cause infection, but the V cholerae is most likely consumption of antacid significantly lowers this number. Do you think an aci 4. The FDA order in this case specifically targeted garlic packed in oil. In what way did the oil help to promote the growth of C. botulinum? (Hint: C.botulinum is an obligate anaerobe-) REFERENCES ???. Botulism. http://emergencycokgov/agent/botulism. Pickand, LK, Gazewish II. Devine B.D, and Shayegani, M.1390 Carlic-in-oil ssociated botulism: Episode leads to produsct modification. Amer.J.Public Health, 80: 1372-1373

Explanation / Answer

1. Botulism is caused by the pathogen Clostridium botulinum. The microbe releases a neurotoxin which binds irreversibly to the presynaptic membranes of peripheral neuromuscular and autonomic nerve junctions. This inhibits the release of acetylcholine, which is a neurotransmitter and muscles are prevented from contraction. Muscles controlled by affected nerves are paralyzed and respiratory arrest occurs resulting in symptoms such as double vision, shortness of breath, slurred speech, diminished gag reflex and muscle weakness.

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