QUESTION1 While the SOS repair pathway can repair devastating pyrimidine dimers,

Question

QUESTION1 While the SOS repair pathway can repair devastating pyrimidine dimers, it comes at a cost. Which of the following best explains the cost of repairing DNA via the SOS repair pathway? The other strand of DNA is used as a template to repair the damaged strand of DNA O A nucleotide is removed so that DNA polymerase Il can move past the pyrimidine dimer. O SOS will help DNA replication bypass pyrimidine dimers but will do so by using random nucleotides in place of the lesion. O The SOS repair pathway uses analogs in place of nucleotides when repairing damaged DNA O There is no consequence to SOS repair and the damaged DNA is repaired precisely back to the wild-type allele. QUESTION 2 Which of the following demonstrates the importance of mutation? O Mutation is the ultimate source of genetic variation and thus is the foundation of why people are interested in genetics in the first o Mutations are always beneficial and thus allow organisms to adapt. O Mutation is not important. place. Mutation will remove variation from the population. Mutation is detrimental to the population and thus is important only because we need to get rid of mechanisms that induce mutations QUESTION 3 Which of the following repair mechanisms requires energy from light? O Removal of alkyl groups using alkyltransferases O SOS repair mechanisms. o recombination-mediated repair O Removal of pyrimidine dimers by the enzyme photolyase. p53 repair pathway

Explanation / Answer

1. The answer is - SOS will help DNA replication bypass pyrimidine dimers but will do so by using random nucleotides in place of the lession.

When DNA is severely damaged SOS response is activated. Higher level of damage caused by UV light or any agent disable DNA polymerase III to continue replication. But this replication is error prone.

2. The answer is- Mutation is the ultimate source of genetic variation and thus is the foundation of why people are interested in genetics in the first place.

Mutation creates genetic variation which is important for evolution.

3. The answer is- removal of pyrimidine dimers by the enzyme photolyase.

DNA photolyase stimulated by light binds to pyrimidine dimers and converts them back to original monomeric nucleotides.

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