4) Classify each of the following mutation as either Framoshift (deletion, inser
ID: 254870 • Letter: 4
Question
4) Classify each of the following mutation as either Framoshift (deletion, insertion) OR Substitution (missense, silent or nonsense) mutation. Use the GENETIC CODE a) Original Wild Type DNA Sequence: TACACCTTGGCGAC GA CT mRNA Sequence: Amino Acid Sequence: AUGUGGAACCGCUGCUGA METHIONINE TRYPTOPHAN- ASPARAGINE-ARGININE-CYSTEINE-(STOP) b) Mutated DNA Sequence #1: T A C A T C T T G G C G A C G A C T What's the mRNA sequence? A U GU AGA A CC GCUGCU G A (Circle the change) What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? C) Mutated DNA Sequence #2: T A C G A C C T T G G C G A C G A C T What's the mRNA sequence? A U G C U G G A A C C G C U G C U G A (Circle the change) What will be the amino acid sequence? Will there likely be effects?What kind of mutation is this? d) Mutated DNA Sequence #3: T A C A C C T T A G C G A C G A C T What's the mRNA sequence? A UGUGGAAUCGCUGCUGA What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this? (Circle the change)Explanation / Answer
4.
b) Mutated DNA sequence #1
Change in the mRNA sequence is A (5th position from left)
What will be the amino acid sequence?
Methionine - Stop
Will there likely be effect?
Yes, mRNA transcription will stop.
What kind of mutation is this?
Non-sense mutation
c) Mutated DNA sequence #2
Change in the mRNA sequence is C U (4th and 5th position)
What will be the amino acid sequence?
Methionine - leucine - Glutamine - Proline - Leucine - Leucine
Will there likely be effect?
Yes, the amino acids in the mRNA sequence will change from the original sequence.
What kind of mutation is this?
A frameshift mutation ( Insertion)
d) Mutated DNA sequence #3
Change in the mRNA sequence is U (9th position from the left)
What will be the amino acid sequence?
Methionine - Tryptophan - Asparigine - Arginine - Cysteine - Stop
Will there be effect?
Yes
What kind of mutation is this?
It is a kind of substitution mutation (missense mutation)
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