This is a genetics question. Can someone please explain this concept to me. If E

Question

This is a genetics question.

Can someone please explain this concept to me.

If ESE's enhance recognition of these splice sites then why is that exon including in the finished product?

AND

If the gene has an ESS - silencer, why is the exon cut out?

It seems to me like it should be the other way around.

Spliceosome Exon nclusion 3'ss 5'ss enhance recognition of these splice sites by spliceosome Exon .3'ss 5'ss Nature Reviews | Immunology silence recognition of these splice sites; thus spliceosome moves right past these sites 69

Explanation / Answer

Exonic Splicing Enhancer (ESE) is a DNA motif with 6 bases in an exon. This ESE directs and enhances splicing of pre-mRNA into messenger RNA (mRNA). The SR proteins bind to these ESE and promote splicing in regions with ESE. The SR proteins bind and cause splicing leaving behind the exon into mRNA. Hence exon is included. ESE just enhance binding and facilitate intron removal leaving behind exon.

On the other hand, the Exon splicing silencer (ESS) silence or inhibit splicing. It promotes exon skipping thereby inhibiting exon inclusion. Hence these ESS cause exon exclusion by silencing the recognition of splice sites and skipping the exon.  

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