Genotypes and Phenotypes of offspring: 4. In humans, susceptibility to migraine
ID: 255217 • Letter: G
Question
Genotypes and Phenotypes of offspring: 4. In humans, susceptibility to migraine headaches is apparently determined by a dominant gene (M) while resistance to migraines is recessive (m). Cystic fibrosis is caused by a recessive gene (c) in humans while one copy of the dominant gene (C) confers a normal phenotype. A man and a woman who do not have the cystic fibrosis phenotype but are both susceptible to migraine headaches marry and have 16 children (hard to imagine!). Nine of the children do not have the cystic fibrosis phenotype but are susceptible to migraine headache; three have cystic fibrosis and are migraine susceptible; three do not have cystic fibrosis and do not get migraines; and one has cystic fibrosis and does not get migraines.Explanation / Answer
Answer:
Genotypes
Man= MMCc or MmCc
Woman = MMCc or MmCc
MC
Mc
mC
mc
MC
MMCC
MMCc
MmCC
MmCc
Mc
MMCc
MMcc
MmCc
Mmcc
mC
MmCC
MmCc
mmCC
mmCc
mc
MmCc
Mmcc
mmCc
mmcc
Genotype
Frequency
Without cystic fibrosis with migraine
MMCC, MMCc, MmCC, MmCc,
MMCc
MmCC
MmCc
MmCc
MmCc
9 or 56.2%
With cystic fibrosis with migraine
Mmcc, MMcc,Mmcc
3 or 18.75%
Without cystic fibrosis without migraine
mmCC
mmCc
mmCc
3 or 18.75%
With cystic fibrosis without migraine
mmcc
1 or 6.2%
MC
Mc
mC
mc
MC
MMCC
MMCc
MmCC
MmCc
Mc
MMCc
MMcc
MmCc
Mmcc
mC
MmCC
MmCc
mmCC
mmCc
mc
MmCc
Mmcc
mmCc
mmcc
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