Chapter 6 Questions The following is a pedigree showing the inheritance of a rar

Question

Chapter 6 Questions The following is a pedigree showing the inheritance of a rare genetic disease. Generation: 8. (I point) 2 6 7 7 8 9 10 11 a) What is the most likely mode of inheritance of this disease (Y-linked, X-linked recessive, linked dominant, autosomal recessive, or autosomal dominant)? Explain why you chose this mode, and how you ruled out all of the óther possibilities. Cite specific individuals from the pedigree to support your answer. b) Based on the mode of inheritance you selected, determine the genotype of each individual (define your symbols)

Explanation / Answer

A). What is the most likely mode inheritance of this disease:

Ans: autosomal dorminant

B).                                                                                                                                                   

INDIVIDUAL

GENOTYPES

#1

XN XN ; XN Xn

#3

XN Xn

        X-linked dominant. Superficially this pedigree appears similar to the pedigree in part (a) in that both males and females are affected, and it appears to be a dominant trait. However, closer inspection reveals that whereas affected females can pass on the trait to either sons or daughters, affected males pass on the trait only to all daughters.

INDIVIDUAL

GENOTYPES

#1

XN XN ; XN Xn

#3

XN Xn

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