2. (2pts each) Consider cargo proteins that are destined for secretion to the ex

Question

2. (2pts each) Consider cargo proteins that are destined for secretion to the extracellular space. Please predict where the cargo will end up (ex. in the cytoplasm, a specific organelle, transport vesicles, multiple places, extracellular space) for: (i) & (ii) Each individual condition; &(ii) The combination of both conditions ton of both cnuar sr A. (i) Normal Sar1 is mutated so it binds tightly to GDP and cannot exchange it for GTP. (This leads to Sar1*-GDP being the only form of the protein in the cell.) (i) COPII coat proteins are mutated so they bind both to active Sar1 and active ARF1 (ii) Both

Explanation / Answer

Answer A (i)

Answer (ii)

Answer (iii)

If both Sar1 and COPII are mutated, it blocks the transport of protein carrying vesicles from ER to Cis Golgi. So, protein remains in ER compartment.

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