QUESTION 4 Cells that undergo an epithelial-to-mesenchymal transition will acqui

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QUESTION 4 Cells that undergo an epithelial-to-mesenchymal transition will acquire O Increased invasive ability. 0 Higher resistance to apoptosis. O Increased motility. O Ability to metastasize. O All of the above. QUESTION 5 Cells undergoing EMT are most frequently observed O In normal tissue surrounding a tumor ?In the center of a tumor . Near the edge of a tumor. Only in circulating tumor cells O None of the above. QUESTION 6 Which of the following is NOT true of matrix metalloproteinases (MMPs)? They degrade the extracellular matrix surrounding tumor cells They inhibit tumor cell invasion They can cleave collagen They can be expressed in macrophages. All of the above. Ctick Save and Submit to save and submit. Click Save All Answers to save all answers,

Explanation / Answer

Question 4

Cells that undergo epithelial to mesenchymal transition will require: All of the above

The biochemical changes that enable a polarized epithelial cell to assume a mesenchymal cell phenotype involve enhanced migratory capacity, resistance to apoptosis and invasiveness.

Question 5

Cells undergoing EMT are most frequently observed - Near the edge of a tumour

Question 6

Which of the following is not true of matrix metalloproteinases(MMPs)

They inhibit tumour cell invasion

MMPs degrade the extra cellular matrix and cleave the collagen. MMPs are also secretary proteins of macrophages.

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