3. One form of chromatin modification is acetylation, which is known to occur on
ID: 257423 • Letter: 3
Question
3. One form of chromatin modification is acetylation, which is known to occur on positively charged histone tail amino acids, thus neutralizing the charge. Based on your understanding of chromatin packaging, we would expect this to (INCREASE/DECREASE/NOT IMPACT) DNA compaction. Which of the following statements best explains your answer? A. The tails do not interact with the DNA B. The tails would now be unable to link together two nucleosomes. C. The tails would now more tightly interact 4. The table to the right is from work done by Oswald Avery's research group tion. The "transforming principle preparation" column on the left refers to the heat-treated smooth (virulent) bacteria. SIII refers to smooth bacteria. R refers to rough (non- virulent). 10.11.01 1 sml Isml sr.lsm + + + 10 0.03 10 a. Which of the following best describes transformation? A. The uptake of foreign material into a cell. B. The conversion of a non-disease causing bacteria into a disease causing one. C. The transfer of novel DNA into a cell b. Which of the following best describes DNA is the genetic material based on his transformation experiments? how Avery contributed to our understanding that A. He showed that B. He showed that addition of a nuclease to a cell sample could block transformation C. He showed that addition of a ribonuclease to a cell sample could block transformation non-disease causing bacteria could become disease causing bacteria lock D. He showed that addition of a protease to a cell sample could b c. Which of the following condlusions would you make based on the table above? Select all that apply A. DNA, and not RNA or protein, is our genetic information B. More "transforming principle preparation results in more transformation C. All replicates of the experiment produced identical results D. Without "transforming principle preparation" added to the reaction, transformation cannot happenExplanation / Answer
Q3. Answer B. The tails would now be unable to link togather two nucleosomes.
Because Acetylation of the lysine residues at the N terminus of histone proteins removes positive charges, reducing the affinity between histones and DNA. This makes RNA polymerase and transcription factors easier to access the promoter region. Therefore, in most cases, histone acetylation enhances transcription while histone deacetylation represses transcription.
Q4. a. Answer B. The conversion of non disease causing bacteria into a disease causing one.
Because the DNA of the disease causing bacteria was absorbed by the non disease causing bacteria resulting in conversion of bacteria.
b. Answer A. He showed that non disease causing bacteria could become disease causing bacteria.
Because it was the transformation of bacteria from non virulent to virulent form using DNA
c. Answer A. DNA and not RNA or proteins is our genetic information.
Because: because it is the DNA alone which results in transformation of cells in Avery experiments.
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