Where is apixaban broken down and metabolized at? Where in the body does alixaba

Question

Where is apixaban broken down and metabolized at?
Where in the body does alixaban get distributed? Which system, organs or tissue does it concentrate?
What does Apixaban do at the biochemically level that causes it to work?
What is the half life of apixaban in the body before it is excreted
Where is apixaban broken down and metabolized at?
Where in the body does alixaban get distributed? Which system, organs or tissue does it concentrate?
What does Apixaban do at the biochemically level that causes it to work?
What is the half life of apixaban in the body before it is excreted

Where in the body does alixaban get distributed? Which system, organs or tissue does it concentrate?
What does Apixaban do at the biochemically level that causes it to work?
What is the half life of apixaban in the body before it is excreted

Explanation / Answer

Apixaban is broken down by liver enzymes in the liver. It is absorbed in stomach and small intestine.

Apixaban acts by inhibiting coagulation and thus prevents development of blood clots. It acts by inhibiting free and clot-bound Xa factor to inhibit coagulation.

Half life of apixaban is 12 hours if taken orally and about 5 hours if taken intravenously.

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